Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
https://www.nature.com/articles/s41467-023-36120-zÂ
New 2013 incidence peak in childhood narcolepsy: more than vaccination?
Zhang Z, Gool JK, Fronczek R, Dauvilliers Y, Bassetti CLA, Mayer G, Plazzi G, Pizza F, Santamaria J, Partinen M, Overeem S, Peraita-Adrados R, da Silva AM, Sonka K, Del Rio-Villegas R, Heinzer R, Wierzbicka A, Young P, Högl B, Manconi M, Feketeova E, Mathis J, Paiva T, Canellas F, Lecendreux M, Baumann CR, Lammers […]
Measurement of symptoms in idiopathic hypersomnia. The Idiopathic Hypersomnia Severity Scale
In a paper published this month in Neurology, the Idiopathic Hypersomnia Severity Scale (IHSS), a brief self-report instrument designed to measure the severity of the key symptoms of idiopathic hypersomnia (IH), was validated. If much is known in the field of narcolepsy, IH remains largely unknown. This central hypersomnia is characterized by severe excessive daytime […]
Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy
The paper of Stephansen et al. in Nature Communications was chosen as the paper of the month of December. In this multicenter study, automated sleep scoring was performed in approximately 3000 normal and abnormal sleep recordings. A deep learning neural network analysis technique was used to produce per subject hypnodensity graphs with 5 s epochs […]
T cells in patients with narcolepsy target self-antigens of hypocretin neurons
It is not every day that narcolepsy is subject to publication in one of the world’s leading science journals, Nature. The paper of Latorre et al. published in September, further supports the hypothesis of an underlying autoimmune process in narcolepsy. The authors (many of them members of the EU-NN), showed for the first time the […]